منابع مشابه
TRAPPing Rab18 in lipid droplets
F ar from being simple storage structures, lipid droplets (LDs) are highly dynamic organelles that are involved in several functions. Testifying to their dynamic nature, several membrane trafficking components are linked to LDs. These include ARF guanine nucleotide exchange factors (GEFs), COPI components, and several Rab GTPases. Despite the fact that almost 40 different Rab GTPases have been ...
متن کاملRab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane.
Lipid droplets (LDs) are organelles that store neutral lipids, but their regulatory mechanism is not well understood. In the present study, we identified Rab18 as an LD component of HepG2 cells by proteomic analysis, and confirmed its localization by immunohistochemistry and western blotting. Wild-type and dominant-active Rab18 localized to LDs but the dominant-negative form did not. Endogenous...
متن کاملRab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets
Hepatitis C virus (HCV) is a single-stranded RNA virus that replicates on endoplasmic reticulum-derived membranes. HCV particle assembly is dependent on the association of core protein with cellular lipid droplets (LDs). However, it remains uncertain whether HCV assembly occurs at the LD membrane itself or at closely associated ER membranes. Furthermore, it is not known how the HCV replication ...
متن کاملLipid droplets
OK, they are cute, but why should a developmental biologist care about them? Onset of calcification early in ontogeny coupled with gradual, progressive morphological development permits the recognition of growth sequences for over a hundred trilobite species. Striking variation in the number of trunk segments at maturity across ontogeny and phylogeny, coupled with the curious pattern of segment...
متن کاملLipid droplets go nuclear
Lipid droplets (LDs) are sometimes found in the nucleus of some cells. In this issue, Ohsaki et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507122) show that the nuclear membrane, promyelocytic leukemia bodies, and the protein PML-II play a role in nuclear LD formation, suggesting functional relationships between these structures.
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2017
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201696287